Ivermectin. Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015

Ivermectin. Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015

JECFA Monographs 18

Year of publication 2016

Pages 37 p.

Publisher FAO/WHO ;

Category Other document

Series title Joint FAO/WHO Expert Committee on Food Additives (JECFA) Monographs

Edition 1

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Synopsis (short abstract) Ivermectin (CAS No. 70288-86-7)2 is a macrocyclic lactone that is a member of the avermectin series and is widely used as a broad-spectrum antiparasitic endectocide against nematode and arthropod parasites in food-producing animals. In human medicine, ivermectin is used to treat onchocerciasis, lymphatic filariasis, strongiloidiasis and scabies. Ivermectin consists of two homologous compounds, 22,23-dihydroavermectin B1a (H2B1a or ivermectin B1a) and 22,23-dihydroavermectin B1b (H2B1b or ivermec tin B1b), in the H2B1a:H2B1b ratio of 80:20. Ivermectin is used in cattle, sheep, goats, pigs, horses, reindeer and American bison at doses of 0.1–0.5 mg/kg bw given subcutaneously, topically or orally, as a single dose treatment only. Withdrawal periods range from 14 to 122 days where ivermectin is approved for use.

Language English

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Diflubenzuron. Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015 2016

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This monograph was also published in: Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015. FAO JECFA Monographs 18.

Diflubenzuron (CAS No. 35367-38-5), besides its use in agriculture, horticulture and forestry against larvae of Lepidoptera, Coleoptera, Diptera, Hymenoptera, and in public health against larvae of mosquitoes, is used as a veterinary drug for the treatment of sea lice (Lepeophtheirus salmonis Kr øyer and Caligus rogercresseyi Boxshall and Bravo, 2000) infestations in Atlantic salmon (Salmo salar L.). Diflubenzuron acts by interference with the synthesis of chitin. Demand for chitin synthesis is greatest at the moult between growth stages and hence parasites are killed due to disruption of the moulting process.
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Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st Meeting, 2015. FAO JECFA Monograph 18 2016

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This volume of FAO JECFA Monographs contains residue evaluation of certain veterinary drugs prepared at the 81st Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Rome, Italy, 17–26 November 2015. This JECFA meeting was convened specifically to consider residues of veterinary drugs in food-producing animal species, to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) a nd/or acute reference doses (ARfDs), and to recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food-producing animals in accordance with good veterinary practice in the use of veterinary drugs. The monographs contained therein provide the scientific basis for the recommendations of MRLs.
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Teflubenzuron. Residue Monograph of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015 2016

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Teflubenzuron is used for the treatment of sea lice in Atlantic salmon, as well as in agriculture to control codling moth, leaf miners, whiteflies and caterpillars on fruit trees, vines, vegetables, potatoes, soybean, tobacco and cotton.

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